Traditional aptamers use just four nucleotides: A, C, G, and T (in the case of DNA aptamers) and A, C, G, and U (in the case of RNA aptamers).
Raptamers™ go further. We generate next-generation aptamers with a backbone made up of standard DNA nucleotides, plus a number of amino acid side chains, through a series of custom modifications that are part of our proprietary process. The side chains give our Raptamers™ more diversity, stronger binding, and increase hydrophobicity, increasing both specificity and antibody-like behavior.
Finally, we have developed a large number of custom modifications that can push binding affinity even further, into the picomolar range!